Glucuronidation and the UDP-glucuronosyltransferases in health and disease.
نویسندگان
چکیده
This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.
منابع مشابه
Udp-glucuronosyltransferases in Sickness and Health Studies on Bilirubin and Steroid Glucuronidation
5 Acknowledgements 7 List of original publications 8 Abbreviations 9
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ورودعنوان ژورنال:
- Drug metabolism and disposition: the biological fate of chemicals
دوره 32 3 شماره
صفحات -
تاریخ انتشار 2004